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LATEST NEWS ON GREEN TEA (EGCG) & HIV |
How Can Epigallocatechin Gallate from Green Tea Prevent HIV-1 Infection? (Web Release Date: January 26, 2006)
Possible inhibitors preventing human immunodeficiency virus type 1 (HIV-1) entry into the cells are recognized as hopeful next-generation anti-HIV-1 drugs. It is highly desirable to develop a potent inhibitor blocking binding of glycoprotein CD4 of the cell with glycoprotein gp120 of HIV-1, because the gp120-CD4 binding is the initial step of HIV-1 entry into the cells. It has been recently reported that (-)-epigallocatechin gallate (EGCG) from green tea is an inhibitor blocking gp120-CD4 binding. But the inhibitory mechanism remains unknown. For understanding the inhibitory mechanism, extensive molecular docking, molecular dynamics simulations, and binding free-energy calculations have been performed in this study to predict the most favorable structures of CD4-EGCG, gp120-CD4, and gp120-CD4-EGCG binding complexes in water. Read more.. Click following
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EGCG (Green Tea) in RetroConference, February 2006 in Colorado
HIV-1 infection ultimately results in impaired immune function by virtue of the initial binding of the HIV envelope glycoprotein, gp120, to the CD4 receptor. The green tea flavanoid, epigallocatechin gallate (EGCG), has been proposed to have medicinal properties including anti-HIV effects. We sought to demonstrate that EGCG binds to the CD4 molecule at the gp120 attachment site and inhibit gp120 binding at physiologically relevant levels.
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Retroconference2006 Green Tea (EGCG) Abstract
Retroconference2006 Green Tea (EGCG) Abstract in PDF format
Green Tea Blocks HIV in Test Tubes
An antioxidant in green tea may block HIV, the virus that causes AIDS, from attaching to an important molecule on immune system cells.
That finding is based on lab tests done on human blood cells, not people. The lab tests were done by Christina Nance, PhD, and colleagues. Nance works in Houston, at Texas Children’s Hospital and Baylor College of Medicine.
In a nutshell, Nance’s team wanted to see if epigallocatechin gallate (EGCG), a chemical found in green tea, might block HIV from attaching to the immune system’s T-helper cells, thus protecting those T cells from HIV’s damage.
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Green Tea Blocks HIV in Test Tubes
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